Law partner Richard Boucher said Makley died Friday. He had been diagnosed with cancer and had also suffered a stroke.
Makley defended Rose beginning in the late 1980s as baseball and Internal Revenue Service officials conducted investigations of the game's career hits leader.
Rose agreed to a lifetime ban from baseball in 1989 for betting on his own team. He applied for reinstatement in 1997, a request that has languished.
Makley served as U.S. attorney in Dayton in 1969 and represented bank officials who faced prosecution after Cincinnati-based Home State Savings Bank collapsed in 1985.
Rose called Makley a good friend and "a topflight attorney."