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Brenly, who managed the Arizona Diamondbacks to the 2001 World Series title, was expected to be among the candidates who would interview with general manager Jim Hendry.
"With all due respect to the organization, to the Ricketts family and to Jim, I just didn't feel at this particular time that this was a good fit for me," Brenly said. "I've said all along that I would love to get back on the field if I felt the situation was right, but for personal and professional reasons, this is not the right time for me."
Brenly said he's been in contact with other teams about managerial opportunities, but he said he loves his broadcasting job and could return in that capacity next season.
Former Florida manager Fredi Gonzalez also withdrew his name. Cubs Triple-A manager Ryne Sandberg and former Cleveland manager Eric Wedge are the only two known to have interviewed for the position. Hendry is still planning conversations with Washington coach Pat Listach, former Arizona manager Bob Melvin and former Seattle Mariners manager Don Wakamatsu.
Interim manager Mike Quade also is being considered.
ESPNChicago.com's Bruce Levine contributed information to this story.
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